Kidney Health
Creatinine, eGFR, and BUN: key kidney function markers.
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Biomarkers Included
3 markersA targeted kidney function panel measuring Creatinine, eGFR, and Urea (BUN). These three markers together provide a baseline view of how well your kidneys are filtering waste products from the blood.
Why this test?
The kidneys filter metabolic waste, regulate fluid balance, and support electrolyte homeostasis. Creatinine and Urea are byproducts of normal metabolism that the kidneys clear from the blood. Measuring them, along with the calculated eGFR, can help indicate how effectively the kidneys are performing this function.
Who is this test for?
This test may be relevant for individuals who consume high-protein diets, use creatine supplementation, or want to establish a baseline for kidney function. It can also be useful for those whose healthcare provider has recommended monitoring renal parameters.
What is tested?
- Creatinine: a waste product from muscle metabolism; elevated levels may suggest reduced kidney filtration.
- eGFR (estimated Glomerular Filtration Rate): a calculated value that estimates how much blood the kidneys filter per minute; derived from creatinine, age, and sex.
- Urea (BUN): a waste product from protein metabolism; levels can be influenced by protein intake and hydration status.
What can this test tell you?
The results may indicate whether kidney filtration is within expected ranges. Elevated creatinine or urea, or a lower-than-expected eGFR, could suggest that the kidneys are working harder than usual. However, these values can also be influenced by muscle mass, protein intake, and hydration, so context matters.
How is the sample collected?
A blood sample is drawn at a certified sample point (afnamepunt). There are over 750 locations across the Netherlands. After placing your order, you can select a location and time that works for you.
When is this test useful?
This test may be useful when you want a focused look at renal function, for example if you are following a high-protein nutrition plan, using creatine, or simply want to establish a baseline for future comparison.
What do the results mean?
Results are presented with reference ranges. Keep in mind that creatinine levels can be naturally higher in individuals with greater muscle mass, and urea can rise with high protein intake. A healthcare provider can help determine whether any values warrant further investigation in the context of your diet and training.
What happens after the results?
Your results are available in your personal dashboard. If any values fall outside the reference range, or if you have questions about what the results mean in the context of your lifestyle, discussing them with a healthcare provider is recommended.
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Receive your lab referral
Within 2-3 hours you'll receive an email from ZorgDomein with a barcode. Orders outside business hours are processed the next business day.
Get tested at a lab near you
Show the barcode on your phone and bring a valid ID. Done in under 15 minutes.
Receive your report from the doctor
A BIG-registered physician assesses your results and writes a personal report. On your dashboard within a few business days.
Choose your markers
Pick a performance panel or build your own test. Testosterone, CRP, ferritin, thyroid. You choose what gets measured.
Receive your lab referral
Within 2-3 hours you'll receive an email from ZorgDomein with a barcode. Orders outside business hours are processed the next business day.
Get tested at a lab near you
Show the barcode on your phone and bring a valid ID. Done in under 15 minutes.
Receive your report from the doctor
A BIG-registered physician assesses your results and writes a personal report. On your dashboard within a few business days.
Always a location near you
With more than 450+ certified phlebotomy points across the Netherlands.
What's Included
This panel covers 3 biomarkers related to your training, recovery, and overall health.
BUN (blood urea nitrogen) measures the amount of urea nitrogen in your blood, a waste product formed when the body breaks down protein. It is primarily used to evaluate kidney function and can be influenced by diet, hydration status, and liver health.
Learn moreCreatinine is a waste product of creatine, a substance your muscles use for energy supply. The kidneys filter creatinine from your blood and excrete it through urine. When the kidneys function less well, creatinine accumulates in the blood. The creatinine level is therefore one of the most important markers for assessing kidney function. It is often measured alongside eGFR, which gives a more precise estimate of how well your kidneys are working.
Learn moreThe eGFR (estimated glomerular filtration rate) estimates how much blood your kidneys filter per minute. It is calculated from your creatinine level, age, sex, and ethnicity using the CKD-EPI formula. eGFR is more accurate than creatinine alone and is used to classify kidney function loss into stages. An eGFR above 90 ml/min is normal; below 60 ml/min indicates clinically relevant kidney function reduction.
Learn moreUrea (BUN)
KidneyBUN (blood urea nitrogen) measures the amount of urea nitrogen in your blood, a waste product formed when the body breaks down protein. It is primarily used to evaluate kidney function and can be influenced by diet, hydration status, and liver health.
BUN is a valuable marker for assessing how effectively your kidneys are filtering waste from your blood. Elevated levels may indicate that the kidneys are not functioning optimally, which can be associated with dehydration, kidney disease, or other underlying conditions. Monitoring BUN alongside other kidney markers such as creatinine and eGFR provides a more comprehensive picture of renal health and helps detect potential problems early.
Creatinine
KidneyCreatinine is a waste product of creatine, a substance your muscles use for energy supply. The kidneys filter creatinine from your blood and excrete it through urine. When the kidneys function less well, creatinine accumulates in the blood. The creatinine level is therefore one of the most important markers for assessing kidney function. It is often measured alongside eGFR, which gives a more precise estimate of how well your kidneys are working.
Chronic kidney damage often progresses silently and rarely causes symptoms in early stages. Your kidneys can lose up to 50% of their function before you notice anything. Creatinine and eGFR are the standard markers for early detection. In diabetes and high blood pressure — the two leading causes of chronic kidney damage — periodic creatinine monitoring is part of clinical guidelines. Kidney function monitoring is also recommended during long-term use of NSAIDs (painkillers such as ibuprofen and diclofenac), ACE inhibitors, or certain antibiotics. An elevated creatinine does not always indicate kidney damage. In people with high muscle mass (strength athletes) or high protein intake, the value can naturally be higher. Conversely, low creatinine in the elderly or in people with little muscle mass can mask reduced kidney function — eGFR is more reliable in those cases.
eGFR (Estimated Glomerular Filtration Rate)
KidneyThe eGFR (estimated glomerular filtration rate) estimates how much blood your kidneys filter per minute. It is calculated from your creatinine level, age, sex, and ethnicity using the CKD-EPI formula. eGFR is more accurate than creatinine alone and is used to classify kidney function loss into stages. An eGFR above 90 ml/min is normal; below 60 ml/min indicates clinically relevant kidney function reduction.
Chronic kidney damage is largely irreversible, but progression can be slowed or stopped if detected early. eGFR is the cornerstone of that early detection. Diabetes and high blood pressure together account for more than 60% of all cases of chronic kidney damage — periodic eGFR monitoring in these patient groups is therefore essential. At an eGFR below 60 ml/min, medication adjustments are often needed because many drugs are excreted by the kidneys. The dosage of contrast agents for CT scans must also be adjusted.
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