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Hematology

Indirect Coombs test: screening for irregular antibodies

The indirect Coombs test screens for unexpected antibodies in your blood that may react against red blood cells. It is an important test for transfusion safety and prenatal care.

Doctor's Assessment Included

Reference Ranges

Expected result Negative

Reference ranges may vary between laboratories. When you order a test, a BIG-registered doctor assesses your personal results in context. For treatment decisions, discuss your results with your GP.

Check your own value

Coombs Test (Indirect): what this test measures

This test detects irregular antibodies circulating in your blood serum that could bind to foreign red blood cells. These antibodies may develop after previous transfusions, pregnancies, or certain immune responses.

Coombs Test (Indirect): why this value matters

Detecting irregular antibodies before a transfusion helps prevent potentially serious transfusion reactions. During pregnancy, the test can identify antibodies that may cross the placenta and affect the baby's red blood cells, allowing timely medical intervention.

Coombs Test (Indirect): how the blood test works

Referral
No GP referral needed. After the order we arrange the referral through ZorgDomein, within one business day; orders after 17:00 or at the weekend start on the next business day. ZorgDomein emails a barcode, and that barcode is what the draw site needs.
The draw
A blood draw from a vein in the arm, at a partner laboratory's draw site. No home kit, no finger prick.
Which test
on its own €33,-
Where
650+ draw sites run by independent laboratories across the Netherlands. Draw sites

Coombs Test (Indirect): when is testing worthwhile?

This test is typically performed before blood transfusions, during pregnancy (especially for Rh-negative women), and as part of pre-operative screening. Consult a healthcare professional for interpretation of results.

Coombs Test (Indirect): lifestyle and this value

Inform healthcare providers of any previous transfusion reactions or known antibodies. Keep your medical records accessible, especially if you have been identified as having irregular antibodies. During pregnancy, attend all scheduled prenatal appointments for timely screening.

Coombs Test (Indirect): frequently asked questions

What does a positive indirect Coombs test mean?

A positive result means irregular antibodies were detected in your blood. This does not necessarily indicate illness, but it is important information for ensuring safe blood transfusions and managing pregnancy. Your healthcare provider will explain the implications for your specific situation.

How is this test different from the direct Coombs test?

The indirect Coombs test detects antibodies floating freely in the blood serum, while the direct Coombs test looks for antibodies already attached to red blood cells. Each test serves a different clinical purpose.

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Medical standards

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Medical policy
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Coombs Test (Indirect)

€33,-